Correlation of serum resistin level with insulin resistance and severity of retinopathy in type 2 diabetes mellitus. Abstract. Resistin is an adipocyte secreted hormone, to investigate the relationship between levels of serum resistin and C- reactive protein (as an inflammatory marker) together with insulin resistance and the presence of retinopathy in type 2 diabetes mellitus in Egyptian subjects, we measured fasting serum resistin and CRP levels in thirty obese diabetic subjects (with different grades of retinopathy: ten diabetic patients without retinopathy, ten diabetic patients with non- proliferative retinopathy and ten diabetic patients with proliferative retinopathy) and compared them with the results of ten obese non diabetic subjects and ten non obese healthy volunteers. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance (HOMA- IR). All subjects were investigated to analyze the change in their total cholesterol, HDL- C, LDL- C, and triglycerides levels. Fasting glucose and insulin resistance were significantly higher (P < 0. Fasting Serum resistin and CRP were highly significantly different among the groups of study (P < 0. Fasting serum resistin concentration showed highly significant positive correlation with CRP, BMI (body mass index), serum insulin, HOMA- I. The Hormone Resistin Links Obesity To Diabetes PdfsThe Hormone Resistin Links Obesity To Diabetes Pdf TypeThe hormone resistin links obesity to diabetes. Increased resistin concentrations might cause insulin resistance and thus could link obesity with type II diabetes. Ghrelin is produced in. The hormone resistin links obesity to diabetes. PDF; All Versions of. Bailey ST, Bhat S et al (2001) The hormone resistin links obesity to diabetes. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish. Nature 409:307–312 CrossRef PubMed. R, and FBS (fasting blood sugar) and it was significantly positively correlated with waist, hip circumferences and triglycerides levels, while it was significantly negatively correlated with HDL- C. Serum resistin was associated with the presence of retinopathy in T2. DM. Keywords. Resistin; Diabetic retinopathy; BMI; CRP; HOMA- I. R; Obesity. 1. Introduction. Resistin is a member of a secretory protein family, known as resistin- like molecules (RELMs) (Steppan and Lazar, 2. A new hormone has been identified that links obesity to type 2 diabetes. It was originally named for its resistance to insulin (Steppan et al., 2. Resistin is expressed in white adipose tissue with the highest levels in female gonadal adipose tissue (Steppan and Lazar, 2. Real- time PCR showed that human resistin was expressed at the highest level in the bone marrow followed by the lung (Patel et al., 2. Human resistin m. RNA has also been detected in the nonfat cells of adipose depots (Fain et al., 2. Resistin was identified as a possible link between obesity and insulin resistance (Chen et al., 2. Insulin resistance is a fundamental aspect of the etiology of type 2 diabetes and is also linked to a wide array of other pathophysiologic sequels including hypertension, hyperlipidemia, atherosclerosis and polycystic ovarian disease (Reaven, 1. A specific complication of diabetes, microangiopathy, includes retinopathy, nephropathy, and neuropathy (Mabley and Soriano, 2. The development or progression of diabetic microangiopathy could be affected by serum resistin (Osawa et al., 2. Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Resistin, a peptide hormone. Resistin, originally described as an adipocyte-specific hormone modulating insulin resistance. Downloads/Links: Online. In recent years, a novel paradigm for the role of adipose tissue in metabolism has emerged. The secretion and release into plasma of biologically active peptides with distant sites of action made the adipocyte an endocrine. Several recent human studies have supported the concept of inflammatory cytokine mediation of resistin (Mattevi et al., 2. BMI, suggesting that resistin may have a direct proinflammatory role or mediate its effects via yet to be discovered obesity- independent mechanisms(Greeshma et al., 2. C- reactive protein (CRP) is an inflammatory biomarker (Sun et al., 2. Torzewski et al., 2. Inflammation as measured by serum C- reactive protein has been shown to be increased in people with diabetes who have macro vascular complications (Zhao et al., 2. Matsumoto et al., 2. In view of this, we investigated the correlation between serum resistin level and insulin resistance in obesity and type 2 diabetes mellitus together with serum resistin and CRP levels in relation to the presence of diabetic retinopathy in fifty Egyptian subjects. Materials and methods. The study was conducted on fifty unrelated Egyptian subjects divided into three groups: group. All subjects were informed of the purpose of the study and their consent was obtained. Physical data for each subject, including weight, height, waist and hip circumferences were recorded. Non diabetic volunteers were judged to be in good health according to their medical history and their fasting blood glucose level (< 1. L). The subjects in group 3 were subjected to fundus examination for detection of the presence of retinopathy and laboratory investigations including, fasting blood glucose level by colorimetric method and fasting serum insulin level (Pal et al., 2. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA- IR), a reliable marker for insulin resistance, was calculated as fasting insulin . Serum resistin was measured using a human resistin ELISA kit (Bender Medsystems, Inc) (Greeshma et al., 2. Subjects also were assayed for C- reactive protein (Ridker et al., 2. Lipid profile (Al- Omar et al.,2. Mehrotra et al.,2. Statistical analysis. The collected data were tabulated and analyzed using SPSS version 1. Categorical data were presented as number and percentages, Chi square test (X2) was used as a test of significance while quantitative data were expressed as mean and standard deviation. Comparison of variables among groups of the study was made by one way analysis of variance (ANOVA). The Student “t” test was used to compare the means for pairs of groups. Correlation between serum resistin and other parameters of the subjects was determined by Pearson’s Product correlation coefficient (r) to test the strength of association between serum resistin and other variables. Bonferroni’s correction was also applied to analyses. Differences were considered statistically significant at P < 0. P< 0. 0. 1, to examine the relationship between serum resistin and retinopathy, simple regression analysis involving retinopathy stage as a dependent variable and serum resistin as an independent variable was performed. The receiver operating characteristic (ROC) curve was used to evaluate the performance of fasting serum resistin level as an indicator of developing retinopathy in diabetic subjects, specificity and sensitivity of different cut off values were estimated. An area under the ROC curve of 1. Zweig and Campbell, 1. Results. Fasting glucose and insulin resistance, as assessed using the homeostasis model of insulin resistance ratio (HOMA- IR), were similar in non obese and obese subjects, but significantly higher (P < 0. Fasting serum resistin was highly significantly (P < 0. Table 1), mean serum resistin concentration increased in ascending manner in the five groups, showing the highest level in subjects with proliferative diabetic retinopathy. Bonferroni adjustment revealed that there was a significant difference between diabetic non retinopathy subjects and subjects with proliferative diabetic retinopathy.
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Denzel Washington also grew a beard in order to emulate the appearance of Rafael P. In Washington's own words: . He has said that he fought with studio executives who wanted to cut the Three Wise Men scene, thinking it slowed the film. He insisted that the Wise Men scene was pivotal in establishing that at least some of Alonzo's illegal actions were sanctioned by his superiors who regarded unethical behavior as a necessary evil. Fuqua wanted Training Day to look as authentic as possible, and he shot on location in some of the most infamous neighborhoods of Los Angeles. He even obtained permission to shoot in the Imperial Courtshousing project, the first time L. A. The crew also filmed in Hoover Block and Baldwin Village. Stones Blood gang members were seen on the rooftops. Cle Shaheed Sloan, the gang technical advisor of Training Day, managed to get on screen real- life gang members from Rollin' 6. Crips, PJ Watts Crips, and B. Stones (a Bloods set). According to Fuqua, the actors and crew ended up receiving a warm welcome from local residents. When he was unable to shoot a scene directly on location, he recreated the locations on sets. There were also two police officers on hand as technical advisors, Michael Patterson and Paul Lozada (the latter from the San Francisco Police Department). Washington, Hawke and other cast members also met with undercover police officers, local drug dealers, and gang members to help them understand their roles better. On review aggregate website Rotten Tomatoes, it has a 7. The website's critical consensus reads, . However, Ebert was bothered by several plot holes and wrote that . At its second week of release, the film's gross revenue was $1. The film stayed in the top- ten box office until the seventh week of release, landing at #1. With an estimated budget of $4. Training Day ultimately grossed $7. It peaked at 3. 5 on the Billboard 2. 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Retrieved 2. 01. 1- 1. Warner Bros. Retrieved 2. Retrieved May 2. 1, 2. Retrieved May 2. 1, 2. Retrieved April 2. Retrieved 2. 01. 1- 1. The Hollywood Reporter. Screen Actors Guild Awards. Retrieved May 2. 1, 2. Retrieved May 2. 1, 2. American Film Institute. Retrieved August 8, 2. Retrieved August 1. Retrieved 2. 0 February 2. |
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